The limitations of clinical trials

[I really should have discussed this before having launched into reviews of evidence from clinical trials as it is fundamental to the issue of what constitutes “evidence”. You will notice, if you read back, that I have peppered my previous posts with links to this article where appropriate.]

I have mentioned in a number of previous posts that there is some evidence for efficacy for some fairly outlandish alternative medicine treatments. This evidence comes in the form of significant statistical tests in clinical trials. Now, clinical trials (double-blind, placebo-controlled and properly randomised) are the gold standard for evidence-based medicine but (as with all statistics) you have to know how to interpret them for them to be of any use. There are three places where care needs to be exercised in the interpretation of clinical trials:Read More »